Dissecting Fibrosis: Examining Cellular Drivers & Uncovering Opportunities for Targeting Fibrosis
- Understanding initiation from insights from preclinical models and single-cell analyses that reveal how epithelial injury, immune cells, and fibroblasts create early fibrotic niches, highlighting actionable targets for early intervention
- Mapping progression and the different cell types that orchestrate extracellular matrix deposition and tissue stiffening, identifying druggable pathways and biomarkers to guide therapeutic development
- Exploring preclinical studies showing fibrosis can regress under certain conditions, with severity- and time-dependent constraints, offering translational opportunities for early markers of reversal to inform clinical endpoints