Engineering Translational Macrophage Models to Build Predictive Preclinical Packages in IPF

• Leveraging patient-derived single-cell signatures in Idiopathic Pulmonary Fibrosis to define translational benchmarks for in vitro macrophage models
• Use high-throughput perturbation platforms to identify stimuli that recapitulate disease-relevant macrophage phenotypes
• Integrate macrophage–fibroblast co-culture systems to capture functional crosstalk and improve predictive confidence in drug discovery

Speakers:

Megan Vierhout

Postdoctoral Fellow

Novartis AG