Exploring Elimination of Senescent Cells Through Harnessing RNA Based Biology
- SENISCA have discovered a new and druggable cause of cellular ageing, dysregulated mRNA processing
- We have designed an RNA therapeutic with a unique MoA capable of restoring levels of splicing regulators back within their homeostatic limits for selective reprogramming of senescent cells
- We have demonstrated efficacy for our new approach in primary human IPF patient cells and in precision cut lung slices from patients with IPF and other interstitial fibrosis disorders