New Target Spotlight Session

• Characterisation of a pathologic link between epithelial MMP7 and CTGF cleavage into a pro-fibrotic, IPF-associated N-terminal fragment
• Description of an ultra-high-affinity anti-CTGF antibody targeting a previously uncharacterized conformational epitope
• Proof of therapeutic principle data using patient-derived complex in vitro models which show anti-CTGF-mediated restoration of alveolar epithelial cell fate and reduced myofibroblast activation

Speakers:

Matt Thomas

Head of Department & Respiratory Exploratory Innovation

Boehringer Ingelheim