Panel Discussion: Rethinking Combination Strategies in IPF: From Preclinical Models to Patient Selection
With momentum building around combination approaches in IPF, this panel will explore how to design smarter strategies grounded in mechanistic complementarity, translatable models, and biomarker-driven patient selection.
Key Talking Points:
- Identifying orthogonal vs. redundant mechanisms to guide rational combination design
- Reassessing preclinical models to better evaluate multi-drug interactions, safety, and efficacy
- Using biomarkers and radiomics to refine patient stratification and predict response
- Defining when standard-of-care therapy isn’t enough and how to optimize add-on strategies for maximum impact