Understanding Fibrotic Disease Through Basket Trial Design & Cross Study Learnings in Progressive Fibrotic ILD

  • What basket and multi-indication trial designs are revealing about shared fibrotic biology across ILD subtypes
  • Key lessons from recent studies including INBUILD, FIBRONEER-ILD, ALOFT and other progressive fibrosis programs
  • How heterogeneous patient populations impact endpoint selection, signal detection, and interpretation of efficacy
  • What these trials teach us about trial design in a combination therapy and background-standard-of-care era