George Washko
Clinical Investigator, Imaging & Quantitative Image Analysis & Associate Physician Brigham and Women's Hospital
Seminars
Thursday 1st October 2026
Visualizing Response in a Multi-Drug Era: Can Imaging Guide Mechanism, Monitor Impact & Inform Smarter Combination Strategies?
3:00 pm
- Exploring how emerging modalities (e.g., cryo-fluorescence tomography, spatial tissue mapping, quantitative imaging) could move beyond static readouts to interrogate where and how therapies are acting within lung compartments—and whether mechanism of action can be localized in vivo
- As pulmonary fibrosis moves toward multi-drug regimens, discussing whether imaging alongside multi-omics could help clarify the relative contribution of individual therapies, including overlapping or complementary mechanisms
- Considering whether serial, spatial imaging could enable more dynamic treatment decisions—guiding when to add, maintain, rotate, or withdraw therapies based on localized response rather than global endpoints
- Outlining current feasibility, key limitations, and what must evolve for imaging-driven treatment optimization to become clinically actionable
