Megan Vierhout
Postdoctoral Fellow Novartis AG
Megan Vierhout, PhD, is a Discovery Postdoctoral Fellow at Novartis in Cambridge, Massachusetts (Disease Area Exploratory and Discovery Sciences). Her research is centered on translational approaches for investigating human macrophage biology and stromal-immune crosstalk in fibrotic disease. Megan obtained her PhD at McMaster University in Hamilton, Canada (Firestone Institute for Respiratory Health and McMaster Immunology Research Center). She has a longstanding research interest in IPF, and through her training has focused on elucidating monocyte and macrophage mediated disease pathogenesis through phenotyping of human lung biopsies, peripheral blood profiling, and ex vivo precision cut lung slice systems.
Seminars
Wednesday 30th September 2026
Engineering Translational Macrophage Models to Build Predictive Preclinical Packages in IPF
2:30 pm
- Leveraging patient-derived single-cell signatures in Idiopathic Pulmonary Fibrosis to define translational benchmarks for in vitro macrophage models
- Use high-throughput perturbation platforms to identify stimuli that recapitulate disease-relevant macrophage phenotypes
- Integrate macrophage–fibroblast co-culture systems to capture functional crosstalk and improve predictive confidence in drug discovery
