Timothy Watkins
Chief Medical Officer & Head of Development Contineum Therapeutics
Seminars
The past year has been transformative for IPF, with new therapies, emerging mechanisms, and evolving patient management strategies reshaping the landscape. This panel will provide a strategic, forward-looking overview of how the field has progressed and what the next 12-18 months may hold. Panellists will discuss the expanding pathophysiology of IPF, emerging classifications of therapies, and implications for patient care, clinical development strategy, and communication with stakeholders.
Key Discussion Points:
- How newly approved therapies and emerging candidates are expected to influence IPF treatment and clinical and research priorities in the next 12–18 months.
- Exploring the practical impact of emerging terminology, anti-fibrotic, anti-inflammatory, de-differentiation, fibrolysis, and how these distinctions may shape patient and clinician preferences
- Approaches for ordering, timing, and combining therapies in a multi-drug era, balancing efficacy, safety, and operational feasibility.
- Identifying opportunities, challenges, and areas for collaboration to ensure trials and programs remain aligned with evolving clinical practice
- Targeting the lysophosphatidic acid 1 receptor (LPA1R), a clinically validated driver of f ibrosis, to disrupt fibroblast recruitment, vascular leak, and pro-fibrotic signalling in IPF
- Reviewing preclinical findings and early clinical data supporting PIPE-791, including differentiation strategy within the LPA1R class and considerations for dose, safety, and patient selection
- Evaluating whether next-generation LPA1R antagonism can overcome historical development challenges and how this programme may fit within combination strategies and evolving standards of care