ADC-Mediated Depletion of Pathogenic Fibroblasts Ameliorates Pulmonary Fibrosis
Time: 9:00 am
day: Day Two
Details:
• Discussing the therapeutic potential of depleting pro-fibrotic fibroblasts
• Using a single-cell-based target discovery engine to target very specific pathogenic sub-populations of cells
• Developing biologics, including antibody-drug conjugates, to deplete target-positive cells
• Evaluating biologics in preclinical models of pulmonary fibrosis to quantify the sensitivity and specificty of cell depletion and the effect on disease-relevant endpoints.