7:30 am
Networking Coffee & Registration
Refocusing IPF Drug Development
Where May Research & Trials Take Us in the Next 12 Months?
Where May Research & Trials Take Us in the Next 12 Months?
8:30 am Illuminating the last 12 months of IPF Drug Development Research
Synopsis
- Highlighting the advancements of research in the last 12 months
- Enlightening the critical inflection point of the IPF research in the next few years
9:00 am Living With IPF: A Patient Perspective
9:20 am Panel Discussion: Thinking to the Future: Where Will the IPF Drug Development Road Take Us?
9:50 am
Speed Networking
Synopsis
- This session is the perfect opportunity to get face-to-face time with the key opinion leaders in the IPF field
- Establish meaningful business relationships to build upon for the rest of the conference and gain individual insight into the pioneering work ongoing
10:35 am
Morning Break & Networking
Basic Science & Early Translational Track
Late Translational & Clinical Track
Validating Novel In Vitro & In Vivo Models: Advancements, Predicting Efficacy, & Navigating Translatability
Utilizing Diagnostic, Prognostic, & Pharmacodynamic Biomarkers in Clinical Trials For a Precision Medicine Approach
11.00 Patient-Specific iPSCs as a Human Preclinical Model of Pulmonary Fibrosis - The epithelial-only patient-specific iAEC2 model system
- Recapitulating key observations made previously in heterologous cell lines, mouse genetic models, and in vivo in the donors from whom the iPSCs were derived
- Providing new insights into the potential role of AEC2s in the inception of pulmonary fibrosis
- Discovering how patient-specific iPSCs are serving as a preclinical platform to test IPF therapeutics
Konstantinos Alysandratos, Assistant Professor, Boston University
11.00 Discussing the Latest in the PROLIFIC Consortium Biomarker Research to be Utilized in PF Clinical Trials
- Moving beyond research using only assays to qualified assays for regulatory purposes and patient management
- Effectively evaluating the 12 biomarkers in IPF research, biomarkers that reflect pharmacodynamics, mechanisms of action and prediction of response
- Discussing the future direction of the PROLIFIC Consortium biomarker research
Peter Schafer, Scientific Vice President, Bristol Myers Squibb
11.30 IN MATRICO® IPF Model: 3D Human Lung Fibrosis Model to Improve Predictiveness and Accelerate Anti-Fibrotic Drug Development
- Establishing a standardized 3D diseased modeling platform which incorporates minimally-processed, human lung extracellular matrix (ECM) to recapitulate the fibrotic disease environment.
- Improving decision-making in early-stage anti-fibrotic drug development by comparing cell viability, protein secretion, and gene expression analysis with standard-of-care compounds and by correlating results with patient-specific data.
Evelyn Aranda, Director of Applications, Xylyx Bio, Inc.
11.30 Can Neoepitope Markers in the Extracellular Matrix Identify Therapeutic Effects on Epithelial Damage in IPF?
- Reviewing how pulmonary Fibrosis (PF) is characterized by epithelial damage and changes to the extracellular matrix (ECM) composition
- Assessing the ECM turnover using the neoepitope technology provides information about tissue equilibrium
- Understanding how neoepitope biomarkers are prognostic in assessing ECM remodelling in fibrotic conditions such as PF
Diana Julia Leeming, Director of Fibrosis, Hepatic and Pulmonary Research, Nordic Bioscience
12.00 Harnessing a Variety of Preclinical Models to Support the Translatability of an Angiotensin Type 2 Receptor Agonist to Clinical Stage
- Leveraging precision-cut human IPF lung slices, primary human lung cell co-cultures, receptor autoradiography, and different animals models of pulmonary fibrosis for preclinical IPF research
- Divulging interim results from an ongoing phase 2 IPF clinical trial to showcase the potential of the therapeutic
Johan Raud, Chief Scientific Officer, Vicore Pharma AB
12.00 Biomarker Prime Time: Rethinking Clinical Research in IPF
- Exploring if biomarkers are able to identify subpopulations of patients, predict disease progression and demonstrate impact of treatment
- Are subpopulations of patients responding differently to treatment?
- How to use the biomarker knowledge effectively in future clinical trials?
Yasmina Bauer, Director & Clinical Biomarker Leader, Galapagos
12:30 pm
Lunch & Networking
1.30 Leveraging Precision-Cut Lung Slices for IPF Research
- Using precision-cut lung slices in translation, and reviewing the available data
- Focusing upon the epithelial injury and how this looks different
- Harnessing knowledge from other models to predict efficacy and navigate the risk of not translating
Hana Cernecka, Head of Inflammation, Bayer AG
1.30 Illuminating Pharmacodynamic Biomarkers: Using Biomarkers Efficiently in IPF Clinical Trials
- Session Details to be Announced
Gregory Cosgrove, Vice President, Clinical Development, Pliant Therapeutics
2.00 Advancing Models that Reflect the Pharmacokinetic & Pharmacodynamic
Properties of Fibrosis
- Highlighting the available data that suggests this approach will be most beneficial
- Understanding the components of the model that reflect the pharmacokinetic and pharmacodynamic properties of fibrosis
- Reflecting on the translatability and usability of this model
Meghan Clements, Principal Scientist, AbbVie
2.00 Panel Discussion: Discussing Effectively Utilizing Biomarkers in Clinical Trials: Which Biomarkers Give Earlier Indication at Trial?
Eric White, Senior Clinical Program Lead – ILD, Boehringer Ingelheim
Peter Schafer, Scientific Vice President, Bristol Myers Squibb
Yasmina Bauer, Director & Clinical Biomarker Leader, Galapagos
2.30 Discussing Collagen Type I mRNA Translation Inhibition in Idiopathic Pulmonary Fibrosis
- Evaluating efficacy of compounds in-vivo in a bleomycin-induced IPF murine model and by Col-I quantification in an ex-vivo system using Human precision-cut-lung-slices (PCLS)
- Highlighting compounds demonstrate tissue selectivity against Lung cells and show no effect on other tissues
Moty Klepfish, Principal Scientist, Fibrosis, Anima Biotech
2.30 Roundtable Interactive Discussion – Putting Biomarkers Into Action: Honing the Use of Biomarkers in the Clinic
An opportunity to break off into smaller groups and choose a discussion topic
- Utilizing the available biomarkers effectively in clinical trials
- Evaluating novel technologies that might give earlier indications at trial
- Is the field closer to having an effective biomarker?
3.00 Panel Discussion: Novel In Vitro Models & Novel In Vivo Models Versus Bleomycin: Do They Better Represent IPF?`
Konstantinos Alysandratos, Assistant Professor, Boston University
Johan Raud, Chief Scientific Officer, Vicore Pharma AB
Hana Cernecka, Head of Inflammation, Bayer AG
Meghan Clements, Principal Scientist, AbbVie
3:30 pm
Afternoon Break & Poster Session
Synopsis
Connect with your peers in a relaxed atmosphere and continue to forge new and existing relationships, whilst exploring the latest IPF drug development advances
To submit a poster or to find out more, contact info@hansonwade.com
Picture This: Novel Lung Imaging Techniques for IPF
4:30 pm Using the Revolutionary Technology Optical Coherence Tomography for IPF Assessment & Diagnosis
Synopsis
- Uncover how optical coherence tomography allows for pulmonologists to examine histological structures in patients’ lungs without the need for biopsy
- Discussing the use of OCT for early diagnosis in ILD patients with low-confidence, clinical-radiologic diagnosis
- Using repeat OCT imaging to detect microscopic disease changes over time, which may have potential for use in phase 2b and phase 3 clinical pharmaceutical trials
5:00 pm Early Disease: Is it There if you Don’t See it?
Synopsis
- Discussing ongoing efforts to study the biology of early and late disease
- Highlighting earlier diagnosis and identification of at-risk individuals